Biological properties

Carcinogenic properties

Thallium is known to produce alterations in the cellular gene expression machinery and the heme biosynthetic pathway. Ionic thallium appears to interfere with the process of ribosomal assembly, causing a number of structural changes in the endoplasmic reticulum in liver cells after acute in vivo injection. This is associated with alterations in the activities of several heme-pathway and heme-dependent enzyme systems [7].

It appears that thallium is capable of interfering with a number of subcellular systems and that these effects may predispose target cell populations to eventual carcinogenic susceptibility [7].